Exonate, an early stage biotechnology company has been awarded a £4.9m seeding drug discovery award by the Wellcome Trust to continue development of an eye drop for treatment of wet age–related macular degeneration.
Exonate is bolstered further by a recent successful funding round of £1.5Million from new and existing shareholders at the end of 2016.
The Wellcome Trust investment will be used to accelerate the development of Exonate’s first in class molecules – a topical eye drug as a much-needed alternative to current treatment by injections for wet age-related macular degeneration.
Exonate have developed small molecules that inhibit production of pro-angiogenic VEGF through selective inhibition of serine/threonine-protein kinase 1 (SRPK1)-mediated VEGF splicing. These inhibitors have already demonstrated superior efficacy as topical agents in preclinical models of wet AMD.
Exonate will take several of these inhibitors into an optimisation programme culminating in the nomination of a preclinical candidate drug with optimal characteristics for clinical development. The funded project will also involve the assessment of the candidate in regulatory toxicology and safety pharmacology studies to support an application to the regulatory authorities for clinical evaluation at the end of the funding. Exonate expects to reach this milestone and enter the clinic in early 2020.
Exonate was delighted with the news that they had been awarded the grant as it means the company can continue to focus on topical delivery of ophthalmology products for diseases of the back of the eye and to expand its science base to address other disease areas. Exonate believes that its approach to wet AMD can provide significant improvements for patients in both efficacy of drug and a reduction in unpleasant injections into the eye. By leveraging the truly global span of this investment Exonate will become a successful company making scientific progress on three continents.
Exonate has an experienced international management team, with a wealth of clinical and start-up experience.
Commenting on the announcement, Dr Catherine Beech, chief executive officer of Exonate, said “I am very pleased that Exonate has been awarded the grant from the Wellcome Trust. This award represents a strong endorsement of the approach taken by the company to discover and develop novel small molecules with a more targeted mode of action. The funding will enable us to accelerate our current programme to develop safer, more cost-effective drugs that can be easily administered as eye drops, improving adherence and benefiting patients. Exonate’s early data is very promising and we have a clear aspiration to successfully deliver medicines in areas of unmet need. We very much look forward to working in close collaboration with the Trust during this funding period.”
Sunil Shah, chairman of Exonate further added “Exonate’s board is delighted to have the backing of the Wellcome Trust. This is a very competitive funding stream, and winning it is testament to the quality of Exonate’s science and management team. The financial support and expertise provided by the Trust will enable the company to execute its strategy to deliver safer and non-invasive treatments to wet AMD patients.”
Uniseed chief executive officer, Peter Devine, said “The Wellcome Trust award further validates the decision to invest into Exonate as it has provided a unique opportunity for Uniseed to get in at the “ground floor” of a drug development program that has been de-risked by being supported by the world’s largest pre-eminent medical research charity funding research into human health.”
Wellcome trust grants, million funds, exonate for developing, amd eye drops
