Amoxicillin is a moderate spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is well absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is one of the most common antibiotics prescribed for children. Amoxicillin is often known for its unappealing taste and odour, which makes the difficulty in formulating paediatric formulation. In the present work, attempts were made to prepare dispersible tablets of amoxicillin trihydrate by direct compression technique to enhance patient compliance. The three super disintegrates used in the study were crosscarmellose sodium, crospovidone and Sodium Starch Glycolate (SSG). The polyelectrolyte complex materials like gum karaya, neem gum and hupu gum are used to prepare the different batches of tablets. The prepared batches of different tablets were evaluated for uniformity of weight thickness, hardness, friability, disintegration test and in vitro dissolution study tablet containing combination of crosscarmellose sodium and crospovidone showed excellent in vitro disintegration time and drug release as compared to other formulations and also characterized for drug excipient interaction using FTIR studies. Morphological size and shape of the particles are characterized by using scanning electron microscopy.
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